Propranolol is non selective beta adrenergic blocking agent and blocks both Beta-1 and Beta-2 receptors. Beta blockers lower blood pressure in hypertension, they don’t induce postural hypotension, because the alpha adrenoceptors remain functional.
Propranolol decreases cardiac output due to its negative inotropic and chronotropic effects. It directly depresses sinoauricular and atriventricular activity. Cardiac output, work and oxygen consumption are decreased by blockage of Beta1 receptors.
Beta receptors dilate blood vessels; blockage of beta receptors prevents vasodilation. The reduced cardiac output leads to decreased blood pressure. This hypotension triggers a reflex peripheral vasoconstriction that is reflected in reduced blood flow to periphery. Hence, gradual reduction of both systolic and diastolic blood pressure in hypertension patients
Reduced blood pressure causes increase in sodium retention and plasma volume. Propranolol also interferes with glucose metabolism leads to decrease glycogenolysis and decreased glucagon secretions.
Beta adrenoceptors present in lungs are also blocked due to Propranolol’s beta receptor blockage; causes bronchoconstriction thus contraindicated in Asthma patients.
Indications:
Side Effects:
Dosage forms:
- Propranolol 10 mg tablets
- Propranolol 20 mg tablets
- Propranolol 40 mg tablets
- Propranolol 60 mg tablets
- Propranolol 80 mg tablets
- Propranolol 40 mg Capsules
- Propranolol 60 mg Capsules
- Propranolol 80 mg Capsules
- Propranolol 20 mg sustain release tablets
- Propranolol 40 mg sustain release tablets
Combinations:
Tablets:
- Propranolol 40 mg + Hydrallazine 25 mg
- Propranolol 20 mg + Alprazolam 0.25 mg
- Propranolol 10 mg + Alprazolam 0.25 mg
- Propranolol 20 mg + Diazepam 2.5 mg
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Carnol from PDC HC
Cenyl from Sykocure
Ciplar from Cipla
Corbeta from SPPL
Corbetazine from SPPL
Etizola Beta from Macleods
Inderal from Piramal HC
Migrales from Dycine
Norten from Baroda
Peelar from Psycorem
Plxna from Aurel
Pranosol from SG Pharma
Proalp from Daffohils Pharma
Prolol from Crescent
Prop-SR from Mediez Pharma
Propal from Svizera HC
Proparise from Sunrise Remedies
Properol from Samarth
Proporise-TR from Sunrise Remedies
Propranolol from Samarth
Proptric-D from Cubit (Cucard)
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Psycool from Solitaire (Psychotop)
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