Raw Material

Propranolol


Propranolol is non selective beta adrenergic blocking agent and blocks both Beta-1 and Beta-2 receptors. Beta blockers lower blood pressure in hypertension, they don’t induce postural hypotension, because the alpha adrenoceptors remain functional.

Propranolol decreases cardiac output due to its negative inotropic and chronotropic effects. It directly depresses sinoauricular and atriventricular activity. Cardiac output, work and oxygen consumption are decreased by blockage of Beta1 receptors.

Beta receptors dilate blood vessels; blockage of beta receptors prevents vasodilation. The reduced cardiac output leads to decreased blood pressure. This hypotension triggers a reflex peripheral vasoconstriction that is reflected in reduced blood flow to periphery. Hence, gradual reduction of both systolic and diastolic blood pressure in hypertension patients

Reduced blood pressure causes increase in sodium retention and plasma volume. Propranolol also interferes with glucose metabolism leads to decrease glycogenolysis and decreased glucagon secretions.

Beta adrenoceptors present in lungs are also blocked due to Propranolol’s beta receptor blockage; causes bronchoconstriction thus contraindicated in Asthma patients.

Indications: 

Hypertension, Glaucoma, Migraine, Hyperthyroidism, Angina pectoris, Myocardial infarction, Anxiety, cardiac arrhythmias etc

Side Effects: 

Tiredness, lack of drive, G.I. upset, nightmares, forgetfulness, rarely hallucinations, muscle fatigue etc

Dosage forms:

  • Propranolol 10 mg tablets
  • Propranolol 20 mg tablets
  • Propranolol 40 mg tablets
  • Propranolol 60 mg tablets
  • Propranolol 80 mg tablets
  • Propranolol 40 mg Capsules
  • Propranolol 60 mg Capsules
  • Propranolol 80 mg Capsules
  • Propranolol 20 mg sustain release tablets
  • Propranolol 40 mg sustain release tablets

Combinations:

Tablets:

  • Propranolol 40 mg + Hydrallazine 25 mg
  • Propranolol 20 mg + Alprazolam 0.25 mg
  • Propranolol 10 mg + Alprazolam 0.25 mg
  • Propranolol 20 mg + Diazepam 2.5 mg
Brand Name  from Company Name:

Albeta-SR from Allenge


Arminol from East West

Betabloc from USV

Betabus from Globus Remedies

Betacap from Sun

Betapro from Consern Pharma

Cardilax from Intas

Carnol from PDC HC

Cenyl from Sykocure

Ciplar from Cipla

Corbeta from SPPL

Corbetazine from SPPL

Etizola Beta from Macleods

HD-SR from Octane Biotech

Inderal from Piramal HC

Lol from Orchid (Mano)
Lol-SR from Orchid (Psychiatry)
Manoprolol from Orchid (Psychiatry)
Migrabeta-TR from Alkem (Pentacare)

Migrales from Dycine

Norten from Baroda

Peelar from Psycorem

Plxna from Aurel

Pranosol from SG Pharma

Proalp from Daffohils Pharma

Prolol from Crescent

Prop-SR from Mediez Pharma

Propal from Svizera HC

Proparise from Sunrise Remedies

Properol from Samarth

Proporise-TR from Sunrise Remedies

Propranolol from Samarth

Proptric-D from Cubit (Cucard)

Provanol from Intas

Psycool from Solitaire (Psychotop)

Siron Plus from Gujurat Terce

Trilol-20 from Triton (Calyx)

About Author

Full Time Blogger, Part Time Entrepreneur and Partial Time Helper for New Start-UP's in Pharmaceutical, Ayurvedic and Nutraceutical Sector. Contact him at pharmafranchiseehelp@gmail.com

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