5-fluorouracil

Strengths 

  • 5-Fluorouracil 250 mg/500 mg injections
  • 5-Fluorouracil 250 mg capsules
Overview:

  • It is used in the treatment of Cancer.
  • 5-Fluorouracil is converted into fluorodeoxyuridine by Thymidine phosphorylase(TP). Fluorodeoxyuridine is then converted into fluorodeoxyuridine monophosphate which is a active metabolite. 
  • 5-FU shows its action by inhibiting DNA synthesis and repair through inhibiting thymidylate synthase(TS) which prevents conversion of deoxyuridine monophosphate into deoxythymidine monophosphate.

Indications:

Anal, breast, colorkectal, oesophageal, stomach, pancreatic and skin cancers (especiallyhead and neck cancers)

Brand Names (Company Name):

5FU-CBC  (MAXICARE)

FLUDIN (BIOLOGICAL E.)

FLURACIL (BIOCHEM )

ONCOURACIL  (TDPL)

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