Nimesulide :
It is a analgesic and antipyretic in action, apart from its anti inflammatory action.
Unlike other NSAIDs the chemical structure of nimesulide does not contain a carboxylic group but a sulfonanillide moiety as the acidic group.
It is absorbed rapidly and completely after oral administration.
It acts by inhibiting the release of tumour necrosis factor alpha, acts as a competitive Inhibitor of histamine release and reduces suproxide anion formation.
Indication:
- Rheumatoid arthritis,
- Osteorthitis,
- Other degenerative joint disorders,
- Musculosketal disorders,
- Low back pain,
- Dysmennorrhoea,
- Gynaecological conditions,
- Thrombophelebitis
- Dental pain and in ent inflamations.