Nimesulide :

It is a analgesic and antipyretic in action, apart from its anti inflammatory action. 

Unlike other NSAIDs the chemical structure of nimesulide does not contain a carboxylic group but a sulfonanillide moiety as the acidic group. 

It is absorbed rapidly and completely after oral administration. 

It acts by inhibiting the release of tumour necrosis factor alpha, acts as a competitive Inhibitor of histamine release and reduces suproxide anion formation.

Indication: 

• Rheumatoid arthritis, 
• Osteorthitis, 
• Other degenerative joint disorders, 
• Musculosketal disorders, 
• Low back pain, 
• Dysmennorrhoea, 
• Gynaecological conditions, 
• Thrombophelebitis 
• Dental pain and in ent inflamations.