Strengths
- 5-Fluorouracil 250 mg/500 mg injections
- 5-Fluorouracil 250 mg capsules
Overview:
- It is used in the treatment of Cancer.
- 5-Fluorouracil is converted into fluorodeoxyuridine by Thymidine phosphorylase(TP). Fluorodeoxyuridine is then converted into fluorodeoxyuridine monophosphate which is a active metabolite.
- 5-FU shows its action by inhibiting DNA synthesis and repair through inhibiting thymidylate synthase(TS) which prevents conversion of deoxyuridine monophosphate into deoxythymidine monophosphate.
Indications:
Anal, breast, colorkectal, oesophageal, stomach, pancreatic and skin cancers (especiallyhead and neck cancers)
Brand Names (Company Name):
5FU-CBC (MAXICARE)
FLUDIN (BIOLOGICAL E.)
FLURACIL (BIOCHEM )
ONCOURACIL (TDPL)