2016

Fluconazole:  It is a big triazole antifungal; drug and is structurally related to imidazole derivative.  It is fungistic in action and exerts its antifungal activity by altering cellular membranes resulting in increased membrane permibility, leakage of essential elements and impaired uptake of precursor molecules. Indication :  Systematic candidiasis,  Mucosal candidiasis and cryptococcosis,  Vaginal candidiasis ,  …

Itopride hydrochloride:  Itopride inhibits the dopamine d2 receptor at thew parsympathetic nerves ends and the metabolism of acetycholine by inhibiting the enzyme acetychlonistrease . by maintaining higher acetychloline levels, itopride increases the esophageal and gastrointestinal paristalsis,increases the lower esophageal sphincter pressure stimulates gastric motility, accelerates gastric emptying and improper gastro duodenal coordination . because of …

Domperidone :    A potent dopamine antagonist with antiemetic properties.  It is useful in the treatment of nausea, vomiting and dyspepsia.  It increases lower oesophageal sphincter pressure antral and duodenal contractions, gastric emptying of liquids and semisolids, and shortens the stationary phase for solid in the stomach. Indication :  Nausea and vomiting associated with electroshock …

Rabeprazole :  It belongs to the class of antisecretory compounds, the substituted benzimidazoles, that suppress gastric acid secretion by the specific inhibition of the H+/K ATPase enzyme at the secreatory surface of the gastric parietal cell and hence are called proton pump blockers. Indication : For the treartment of active duodenal ulcer.  Active benign gastric …

Glucosamine sulphate :  Glucosamine sulphate is an amino sugar, which builds up the volume of naturally present glucosamine in the body.  The increased of glucosamine level, in turn accelerates the biosynthesis of building blocks of cartilage. Indication :  In painful conditions of osteoarthritis and rheumatoid arthritis, where aspirin and other NSAIDs fail to provide a …

Diacerein:  It is an anthrquinone derivative.  It inhibits interiukin -1, an important cytokine implicated in osteoarthritis.  Diacerein has beneficial effects on the anabolic processes that occur in the cartilage.  It increases the production of transforming growth factor – b that triggers chondrocyte proliferation and stimulates the production of coilagen, proteglycans and hyaluroan . Indication :  …

Sparfloxacin :  It is an aminofluoquinoline and exerts its antibacterial activity via the inhibition of DNA replication of bacteria by inhibiting DNA gyrase activity.  Its absorption begins soon after oral administration. The distribution of sparfloxacin in nasal mucosa and sinus muucosa is primarily high.  It is metabolized by the liver to an inactive acylglucuronide conjugate.  …

Ondansetron: It is a potent higly selective antagonist at the 5 hydroxytryptamine receptors sbtype 3 . It can effectively control vomiting due to anticancer drugs as well as raitherapy .unlike metocloprmide , Ondansetron is not a lopomide antagonist and doesnot cause dystonia or extra pyramidal effects.  It is a carbazole with causes antinauseant and antiemtic …

L-Ornithine: Indication :  Acute and chronic liver disease fatty liver . Hepattis and post hepattis  Convalescence cirrhosis , Prophylaxis and treatment of drug induced hepatitis

GABAPENTINE: It is a valueable adjunct to other antiepileptic drugs in adult patients who have not achieved adequate control of partial seizures with these agents used alone or in combination . It has simple pharmacokinetic profile and is not protein bound . Indication: Adjunctive therapy in the treatment of partial seizures with secondary generalization . …