Fluconazole:

It is a big triazole antifungal; drug and is structurally related to imidazole derivative. 

It is fungistic in action and exerts its antifungal activity by altering cellular membranes resulting in increased membrane permibility, leakage of essential elements and impaired uptake of precursor molecules.

Indication : 

• Systematic candidiasis, 
• Mucosal candidiasis and cryptococcosis, 
• Vaginal candidiasis , 
• Fungal infections in patients with malignancy.