These are alpha agoinst which on topical application as dilute solution (0.05-0.1% ) produce local vascocostruction. 
The imidazoline compounds- naphazoline, xylometazoline and oxymetazoline are relatively selective a2 agoinst like chlonidine. 
They have a longer duration of action than emphedrine. After congestion is claimed to be less than the ephiderine or phenylephrine. May cause initial stinging sensation

Indication : 

  • Nasal congestion.
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