Methyldopa

Methyldopa

It is moderate efficacy antihypertensive; primarily decreases total peripheral resistance with little effect on cardiac output.
Methyldopa is a competitive inhibitor of the enzyme aromatic L-amino acid decarboxylase (DOPA decarboxylase) which is responsible for conversion of L-Dopa into dopamine.
It is also converted α-methylnorepinephrine by dopamine β-hydroxylase.

Indication: 

Mild to moderate hypertension etc.

Side Effects: 

Sedation, lethargy, reduced mental capacity, dry mouth, fluid retention, nasal congestion etc.

Dosage Forms:

Methyldopa 250 mg tablets

Combinations:


Brand Names (Company Name):

Methyl Dopa (Unicure (India) Pvt.Ltd.)

Aldopam (Neon Labs)
Alphadopa (Wockhardt (Merind))
Dopagyt (Themis Pharma)
Emdopa (IDPL)
Gynapres (Mankind)
Sembrina (Sanofi Aventis) 
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