Methyldopa
Methyldopa
It is moderate efficacy antihypertensive; primarily decreases total peripheral resistance with little effect on cardiac output.
Methyldopa is a competitive inhibitor of the enzyme aromatic L-amino acid decarboxylase (DOPA decarboxylase) which is responsible for conversion of L-Dopa into dopamine.
It is also converted α-methylnorepinephrine by dopamine β-hydroxylase.
Indication:
Mild to moderate hypertension etc.
Side Effects:
Sedation, lethargy, reduced mental capacity, dry mouth, fluid retention, nasal congestion etc.
Dosage Forms:
Methyldopa 250 mg tablets
Combinations:
Brand Names (Company Name):
Methyl Dopa (Unicure (India) Pvt.Ltd.)
Aldopam (Neon Labs)
Alphadopa (Wockhardt (Merind))
Dopagyt (Themis Pharma)
Emdopa (IDPL)
Gynapres (Mankind)
Sembrina (Sanofi Aventis)
