It is amide derivative of the local anaesthetic procaine which was found to have antiarrhythmic activity but was not suitable clinically due to rapid hydrolysis and marked C.N.S. effects. It inhibits sodium channel and prolongs the cardiac action potential. Restrict entry of sodium and block outward potassium current.


Premature ventricular contraction & Tachycardia, cardiac arrhythmia, Atrial Fibrillation, Paroxysmal atrial tachycardia etc

Side Effects: 

Nausea, Vomiting, weakness, mental confusion, hallucinations, flushing, hypotension etc

Dosage Forms:

  • Procainamide HCL 250 mg tablets
  • Procainamide HCL 100 mg/ml (10 ml) injections

Brand Names:

  • Pronestyl 
  • Procan SR 
  • Procanbid
  • Pronestyl-SR
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