It reduce gastric acid secretion through a highly selective mechanism of action.
It produces specific dose dependent inhibition of the enzyme”h+,k+,atpase in the parietal cell.as this action inihibts the final stage of gastric acid formation
There is effective inhibition of both casual and stimulated acid secretion irrespective of the stimulus to acid formation .
- Duodenal ulcer,
- Gastric ulcer,reflux oesophagitis.
- Zollinger Ellison syndrome