It has major haemodynamic effects result from action on central sites in medulla and hypothalamus.

Clonidine stimulates α2- receptors in brain thus decreases peripheral vascular resistance and lowers blood pressure. This decreases presynaptic calcium levels and inhibit the release of norepinephrine. This effect decreases sympathetic tone.


All grades of Hypertension etc.

Side effects: 

Sedation, dry mouth, dizziness, constipation, sleep disturbance, impotence etc.

Dosage Forms:

Clonidine HCL 100 mcg tablets
Clonidine HCL 150 mcg tablets


Clonidine HCL 100 mcg + hydrochlorothiazide 20 mg
Clonidine HCL 100 mcg + hydrochlorothiazide 12.5 mg
Clonidine HCL 100 mcg + Chlorthalidone 15 mg

Brand Names:

Arkamin (Unichem Laboratories Ltd.)

Catapres (Zydus Cadila Healthcare Ltd. (German Remedies))
Clodict (Consern Pharma Pvt Ltd. )
Clonidine Hydrochloride (Neon Laboratories Ltd )
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