Day: June 7, 2016

PIPERACILLIN  Piperacillin is a broad spectrum beta lactam antibiotic of the ureidopenicillin class Indication :  In moderate to severe infections caused by piperacillin resistant,  Piperacillin suspectible,  Beta lactamase producing strains,  In appendicitis, peritonitis,  Skin/soft tissue infection,  Lower respiratory tract infections,  Infection in neutropenic patients,  Intra abdominal infection and UTI.

TRIAMCINOLONE:  It is slightly more potent than prednisolone selectiveucocortoid.  It has virtually no sodium retaining effect, but has the disadvantages that muscle wasting may occasionally be severe and anorexia, mental depression may be more common at high doses. Indication:  Rheumatoid arthritis,  Asthma,  Allergies,  Dermatoses

NANDROLONE DECANOATE:  These are synthetic androgens with higher anabolic steroids were developed with the idea of avoiding virlizing side effects of androgens while retaining the anabolic effects.  They tend to increase retention of nitrogen, calcium, sodium, potassium, chloride and phosphate, leading to an increase in skeletal weight, water retention and increase growth of bone.  Situations…

AMIKACIN:  It is a semisynthetic aminoglycoside virtually identical to its parents compound kanamycin.  Amikacin is effective against a variety of aerobic gram negative bacilli including those that are resistant to gentamicin and other aminoglycosides. Escherichia coli indole positive and negative proteus species klebsiella, enterobacter, serratia acinetobacter , citrobecterfreundil and providencia stuatii  It is effective against…

SUCRALFATE :  It is a basic aluminium salt of sulfated sucrose, infrequently viscous in acidic medium, polymerizing into a sticky gel like consistency.  It precipitate surface proteins at ulcer base and acts as acid resistant physical barrier preventing acid, pepsin and bile from coming in contact with the ulcer base. Indication :  Duodenal and gastric…

HYDROCHOROTHIAZIDE:  It inhibits the active reabsorption of sodium ,chiefly in the distal renal tubule ,thus increasing the excreation of sodium chloride and water.  Cardiac output and both extracellular and plasma volume decrease and during long term treatment peripheral vascular resistance diminishes. Combined treatment with other drugs used for the treatment of hypertension potentiates in the…

METFORMIN:  They are completely different from the hypoglycaemic sulfonamides both in its structure and its mode of action . They cause little or no hypoglycaemia in non diabetic .possible mode of action suggested is that they interfere with mitochondrial respiratory chains promote peripheral glucose utilization by enhancing anaerobic glycolysis or they enhance binding of insulin…

GLIMEPRIDE: It is a hypogycaemic agent belonging to the second generation sulfonylureas .  It appears to lower blood glucose by stimulating insulin release from beta cells in the pancreatic islets possibly due to increased intracellular cAMP Indication: Non insulin dependent diabetes.

TELMISARTAN:  It acts by blocking the vasoconstrictor and aldosterone secreting effects of angiotensim 2 by selectively blocking the binding of angiotensin 2 to the at1 receptor in main tissue such as vascular smooth muscle and the addernal gand . Its action is ,therefore , independent of the pathways for angiotensin 2 synthesis .  It has…

ATENOLOL: It is a relatively cardio selective andreoceptor blocking agent without membrane stabilizing or intrinsic sympathomimetic activities Indication: Hypertension , Angina pectoris ,  Myocardial infarction .